Second Location: Beginning in August 2026, we will see patients on Tuesdays at our new location: 8888 Ladue Road, Suite 105, St. Louis. Our primary location at 4800 Mexico Rd in St. Peters will be closed on Tuesdays. We look forward to welcoming you to our new space!
Tylenol (Acetaminophen) Allergy
Have you experienced skin reactions, swelling, or difficulty breathing after taking Tylenol? Board-certified allergist Dr. Sonia Cajigal can help you determine if you have a Tylenol allergy or hypersensitivity. Get a formal diagnosis and learn what medications are safe for you to take. Schedule your visit with us at St. Louis Family Allergy today!
“Dr. Cajigal was friendly, professional, and informative. She took the time to explain the tests and what was going on with my allergies. She is so knowledgeable and really cared about how I was feeling. I would highly recommend this practice if you suffer from allergies and asthma.”
– Sue D, July 2020
About Tylenol Allergy
Allergy or Hypersensitivity?
in St. Louis, Missouri
Tylenol Allergy vs Hypersensitivity
Hypersensitivity, on the other hand, refers more broadly to any immune-mediated response to a substance, including delayed and non-IgE types (Types I to IV). A retrospective review of oral challenge tests in children with suspected acetaminophen hypersensitivity found only about 10% had positive reactions, and most were non-life-threatening and mild (such as hives or rash).
Tylenol Allergy Symptoms
Tylenol allergy symptoms (IgE-mediated) occur within minutes to an hour of consumption, and may include:
- Hives (urticaria)
- Swelling of the lips or face (angioedema)
- Cough, throat tightness, or difficulty breathing
- Wheezing or asthma-like symptoms
- Anaphylaxis (extremely rare)
Tylenol hypersensitivity symptoms (T-cell-mediated) occur hours to days after consumption, and may include:
- Maculopapular Rash – a widespread, flat red rash
- Fixed Drug Eruption (FDE) – recurring rash in the same spot
- Stevens-Johnson Syndrome (SJS) or Toxic Epidermal Necrolysis (TEN) – very rare but serious
- DRESS Syndrome (Drug Reaction with Eosinophilia and Systemic Symptoms) – rash, fever, liver or other organ involvement
in St. Louis, Missouri
Tylenol Allergy Testing
Unlike more common allergies, there are no validated skin or blood tests used for Tylenol allergy testing. Diagnosis is largely clinical, and may include:
- A detailed history of the reaction
- An oral challenge test under medical supervision
- Occasionally, patch testing or delayed intradermal testing may also be used
Living with Tylenol Allergy
We hope you’ve found this information helpful. Get in touch with us at St. Louis Family Allergy to learn more about Tylenol allergy and how to most effectively manage it. We’re looking forward to your visit!
References
[2] Gabrielli S, Langlois A, Ben-Shoshan M. Prevalence of Hypersensitivity Reactions in Children Associated with Acetaminophen: A Systematic Review and Meta-Analysis. Int Arch Allergy Immunol. 2018;176(2):106-114
[3] American College of Allergy, Asthma & Immunology: https://acaai.org/
[4] Asthma and Allergy Foundation of America: https://www.aafa.org/
Asthma
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Drug Allergy Specialist
Dr. Sonia Cajigal
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